Faculty Information - Ikeya Teppei

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Academic background

Research Overview

Present specialized field

Research activities

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（Last updated : 2026-09-07 11:52:09）

Ikeya Teppei
Department of Life Science, Faculty of Advanced Engineering

Graduate School of Engineering

Master's Program in Life Science, Graduate School of Advanced Engineering

Professor

■ Office

Tsudanuma Campus, No.1 Building,4th floor room 020407

■ Academic background

〔Doctorial Course〕, The University of Tokyo, Completed,

■ Research Overview

My research focuses on investigating the structures, functions, and interactions of biological macromolecules, such as proteins, using physicochemical techniques—primarily NMR spectroscopy and small-angle X-ray scattering (SAXS)—with the aim of advancing the understanding of biological phenomena and contributing to applications such as drug discovery. I also develop new methods for NMR measurements and data analysis.

■ Present specialized field

Biophysics, Structural biochemistry (Key Word：Protein Science, NMR, Computational Chemistry, Data Science)

■ Research activities

2022/04～2025/03

∟ Councilor

■ Works

1.	Book	Experimental approaches of NMR spectroscopy -Methodology and application to life science and materials science 2nd Ed. Springer (Collaboration) 2025
2.	Article	Development and biological characterization of the cyclic peptide cRGDTFI with potent binding affinity for integrins αvβ3 and αvβ5 Materials & Design 257,pp.114466-114466 (Collaboration) 2025/09/01
3.	Article	A Methionine-Rich Repeat Forms a Spiral Conformation That Guides Aragonite Nanofiber Organization in Molluscan Ligaments Biomacromolecules (Collaboration) 2025/08/29
4.	Article	Multistate Structure Determination and Dynamics Analysis Reveals a Unique Ubiquitin-Recognition Mechanism in Ubiquitin C-terminal Hydrolase Journal of the American Chemical Society (Collaboration) 2025/08/06
5.	Article	Development and Biological Characterization of the Cyclic Peptide Crgdtfi with Potent Binding Affinity for Integrins Αvβ3 and Αvβ5 Social Science Research Network (SSRM) (Collaboration) 2025/08/01
6.	Article	Backbone and side‑chain 1H, 13C and 15N resonance assignments and secondary structure determination of the rhizobial FixJ Biomolecular NMR Assignments pp.77-82 (Collaboration) 2025/02/01
7.	Article	Different molecular recognition by three domains of the full-length GRB2 to SOS1 proline-rich motifs and EGFR phosphorylated sites. Chemical science 15(38),pp.15858-72 (Collaboration) 2024/09/12
8.	Article	Structure and Dynamics of Drk-SH2 Domain and Its Site-Specific Interaction with Sev Receptor Tyrosine Kinase International Journal of Molecular Sciences 25(12),pp.6386-6386 (Collaboration) 2024/06/09
9.	Article	Structural and Functional Analysis of the Amorphous Calcium Carbonate-Binding Protein Paramyosin in the Shell of the Pearl Oyster, Pinctada fucata Langmuir 40(16),pp.8373-8392 (Collaboration) 2024/04/12
10.	Article	Structural and biochemical insights into heterotetramer formation of oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator Life Science Alliance 7(1),pp.e202302080-18 (Collaboration) 2023/09/01
11.	Article	Interactions of the N- and C-terminal SH3 Domains of Dro-sophila Drk with the proline-rich peptides from Sos and Dos International Journal of Molecular Sciences 24,pp.14135-14145 (Collaboration) 2023/09
12.	Article	Structural and Functional Analyses of the Acidic and Basic Amino Acid Repeat Sequence (DDRK) in Pif 80 from Pinctada fucata on the Aragonite Crystal Surface Using NMR Crystal Growth & Design 23(7),pp.5264-5278 (Collaboration) 2023/06/23
13.	Article	Protein structural analysis in living cells and for multiple conformations using solution NMR (Collaboration) 2023
14.	Article	Insight into the C-terminal SH3 domain mediated binding of Drosophila Drk to Sos and Dos. Biochemical and biophysical research communications 625,pp.87-93 (Collaboration) 2022/10/15
15.	Article	Structural insights into the complex of oncogenic KRas4B^G12Vand Rgl2, a RalA/B activator bioRxiv (Collaboration) 2022/10/10
16.	Article	Molecular mechanism of glycolytic flux control intrinsic to human phosphoglycerate kinase Proceedings of the National Academy of Sciences 118(50) (Collaboration) 2021/12/10
17.	Article	Targeting chromosome trisomy for chromosome editing Scientific Reports 11(1) (Collaboration) 2021/09/10
18.	Article	Multi-state structure determination and dynamics analysis reveals a new ubiquitin-recognition mechanism in yeast ubiquitin C-terminal hydrolase Biorxiv (Collaboration) 2021/04/22
19.	Article	Recent progress of protein structure calculation by solution NMR Agri Bio (Collaboration) 2021
20.	Article	Recent progress of protein structure calculation by solution NMR Saibou pp.48-52 (Collaboration) 2021
21.	Article	Protein structure determination in living cells from NOE-derived distance restraints New Developments in NMR 2020-(21),pp.65-89 (Collaboration) 2020
22.	Article	Paramagnetic relaxation enhancement‐assisted structural characterization of a partially disordered conformation of ubiquitin Protein Science 28(11),pp.1993-2003 (Collaboration) 2019/10/18
23.	Article	Protein Structure Determination in Living Cells International Journal of Molecular Sciences 20(10),pp.2442-2442 (Collaboration) 2019/05/17
24.	Article	High-Resolution Protein 3D Structure Determination in Living Eukaryotic Cells ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58(22),pp.7284-7288 (Collaboration) 2019/05
25.	Article	New Developments in MMR Series: In-cell NMR Spectroscopy: From Molecular Sciences to Cell Biology The Royal Society of Chemistry (Collaboration) 2019
26.	Article	Solution NMR views of dynamical ordering of biomacromolecules Biochimica et Biophysica Acta (BBA) - General Subjects 1862(2),pp.287-306 (Collaboration) 2018/02
27.	Article	Protein NMR Structure Refinement Based on Bayesian Inference for Dynamical Ordering of Biomacromolecules Journal of Computer Chemistry, Japan pp.65-75 (Collaboration) 2018
28.	Article	Advances in NMR data acquisition and processing for protein structure determination Experimental Approaches of NMR Spectroscopy: Methodology and Application to Life Science and Materials Science pp.63-90 (Collaboration) 2017/11/23
29.	Article	Experimental approaches of NMR spectroscopy Springer (Collaboration) 2017
30.	Article	Improved in-cell structure determination of proteins at near-physiological concentration Scientific Reports (Collaboration) 2016/12/02
31.	Article	A specific single-stranded DNA induces a distinct conformational change in the nucleoid-associated protein HU. Biochemistry and biophysics reports 8,pp.318-324 (Collaboration) 2016/12
32.	Article	A new carbamidemethyl-linked lanthanoid chelating tag for PCS NMR spectroscopy of proteins in living HeLa cells JOURNAL OF BIOMOLECULAR NMR 66(2),pp.99-110 (Collaboration) 2016/10
33.	Article	Protein NMR Structure Refinement based on Bayesian Inference Journal of Physics: Conference Series 699(1),pp.012005-012005 (Collaboration) 2016/04
34.	Article	Application of Sparse Modeling to Biological NMR The Journal of the Institute of Electronics, Information and Communication Engineers pp.439-443 (Collaboration) 2016
35.	Article	Evaluation of the reliability of the maximum entropy method for reconstructing 3D and 4D NOESY-type NMR spectra of proteins BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 457(2),pp.200-205 (Collaboration) 2015/02
36.	Article	Automated resonance assignment of the 21kDa stereo-array isotope labeled thioldisulfide oxidoreductase DsbA. Journal of magnetic resonance (San Diego, Calif. : 1997) 249,pp.88-93 (Collaboration) 2014/12
37.	Article	Influence of NMR Data Completeness on Structure Determinations of Homodimeric Proteins Journal of the Chinese Chemical Society 61(12),pp.1297-1306 (Collaboration) 2014/08/27
38.	Article	An in-cell NMR study of monitoring stress-induced increase of cytosolic Ca2+ concentration in HeLa cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 438(4),pp.653-659 (Collaboration) 2013/09
39.	Article	NMR Solution Structure of a Chymotrypsin Inhibitor from the Taiwan Cobra Naja naja atra Molecules 18(8),pp.8906-8918 (Collaboration) 2013/07/26
40.	Article	Structure, Dynamics and Folding Stability of Proteins Inside Living Cells : Recent Findings from In-cell NMR Studies Seibutsu Butsuri pp.76-81 (Collaboration) 2013/03/25
41.	Article	High-Resolution Heteronuclear Multidimensional NMR of Proteins in Living Insect Cells Using a Baculovirus Protein Expression System JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 135(5),pp.1688-1691 (Collaboration) 2013/02
42.	Article	Exclusively NOESY-based automated NMR assignment and structure determination of proteins JOURNAL OF BIOMOLECULAR NMR 50(2),pp.137-146 (Collaboration) 2011/06
43.	Article	Structural investigation of the C-terminal catalytic fragment of presenilin 1 Proceedings of the National Academy of Sciences 107(21),pp.9644-9649 (Collaboration) 2010/05/05
44.	Article	NMR protein structure determination in living E. coli cells using nonlinear sampling NATURE PROTOCOLS 5(6),pp.1051-1060 (Collaboration) 2010
45.	Article	Conformational stability and activity of p73 require a second helix in the tetramerization domain Cell Death & Differentiation 16(12),pp.1582-1589 (Collaboration) 2009/09/18
46.	Article	Automated NMR structure determination of stereo-array isotope labeled ubiquitin from minimal sets of spectra using the SAIL-FLYA system Journal of Biomolecular NMR 44(4),pp.261-272 (Collaboration) 2009/07/14
47.	Article	Protein structure determination in living cells by in-cell NMR spectroscopy NATURE 458(7234),pp.102-U10 (Collaboration) 2009/03
48.	Article	Structure of the putative 32 kDa myrosinase-binding protein from Arabidopsis (At3g16450.1) determined by SAIL-NMR. The FEBS journal 275(23),pp.5873-84 (Collaboration) 2008/12
49.	Article	Solution structure of the c-terminal dimerization domain of SARS coronavirus nucleocapsid protein solved by the SAIL-NMR method. Journal of molecular biology 380(4),pp.608-22 (Collaboration) 2008/07/18
50.	Article	Automated structure determination of proteins with the SAIL-FLYA NMR method. Nature protocols 2(11),pp.2896-902 (Collaboration) 2007
51.	Article	Evaluation of stereo-array isotope labeling (SAIL) patterns for automated structural analysis of proteins with CYANA. Magnetic resonance in chemistry : MRC 44 Spec No,pp.S152-7 (Collaboration) 2006/07
52.	Article	Heteronuclear multidimensional NMR and homology modelling studies of the C-terminal nucleotide-binding domain of the human mitochondrial ABC transporter ABCB6 Journal of Biomolecular Nmr pp.53-71 (Collaboration) 2006
53.	Article	Design of lambda Cro fold: Solution structure of a monomeric variant of the de novo protein JOURNAL OF MOLECULAR BIOLOGY 354(4),pp.801-814 (Collaboration) 2005/12
54.	Article	Molecular analysis of genes expressed during the calcification of the exoskeleton of the decapod crustacean Penaeus japonicus, in Biomineralization: formation, diversity, evolution and application Tokai University Press pp.149-152 (Collaboration) 2003
55.	Article	The DD5 gene of the decapod crustacean Penaeus japonicus encodes a putative exoskeletal protein with a novel tandem repeat structure Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 128(3),pp.379-388 (Collaboration) 2001/03
56.	Article	Formation of the Calcified Exoskeleton in the Prawn, Penaeus japonicus. In Calcium Metabolism: Comparative Endocrinology BioScientifica Ltd, Bristol pp.1-6 (Collaboration) 1999
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■ Home Page

https://spinhalflock.github.io/biophyschem/index_en.html

https://researchmap.jp/teppei-ikeya